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W Koek Selected Research

5-HT1A Serotonin Receptor

1/2018NLX-112, a highly selective 5-HT1A receptor agonist: Effects on body temperature and plasma corticosterone levels in rats.
9/2015NLX-112, a novel 5-HT1A receptor agonist for the treatment of L-DOPA-induced dyskinesia: Behavioral and neurochemical profile in rat.
4/2003Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain.
11/2002Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
12/2001Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5-HT(1A) receptors expressed in HeLa cells.
6/2001In the formalin model of tonic nociceptive pain, 8-OH-DPAT produces 5-HT1A receptor-mediated, behaviorally specific analgesia.
7/2000The putative <<silent>> 5-HT(1A) receptor antagonist, WAY 100635, has inverse agonist properties at cloned human 5-HT(1A) receptors.
4/2000Effects of WAY 100635 on antipsychotic-induced catalepsy in 5-HT depleted animals: a role for tonic activation of 5-HT(1A) receptors.

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W Koek Research Topics

Disease

6Pain (Aches)
01/2018 - 03/2001
3Catalepsy
09/2015 - 04/2000
3Nociceptive Pain
04/2003 - 03/2001
2Dyskinesias (Dyskinesia)
01/2018 - 09/2015
2Chronic Pain
04/2003 - 07/2002
2Carcinoma (Carcinomatosis)
12/2001 - 07/2000
1Hypothermia
01/2018
1Mood Disorders (Mood Disorder)
09/2015
1Parkinson Disease (Parkinson's Disease)
09/2015
1Schizophrenia (Dementia Praecox)
06/2015
1Mental Disorders (Mental Disorder)
06/2015
1Opioid-Related Disorders (Opiate Addiction)
12/2008
1Shock
12/2008
1Hyperalgesia
11/2002
1Neuralgia (Stump Neuralgia)
11/2002
1Body Weight (Weight, Body)
07/2002
1Alzheimer Disease (Alzheimer's Disease)
12/2001
1Retrograde Amnesia
12/2001
1Experimental Arthritis
03/2001
1Substance-Related Disorders (Drug Abuse)
12/2000
1Cocaine-Related Disorders (Cocaine Addiction)
12/2000

Drug/Important Bio-Agent (IBA)

85-HT1A Serotonin ReceptorIBA
01/2018 - 04/2000
4befiradolIBA
01/2018 - 11/2002
4LigandsIBA
04/2003 - 07/2000
3Opioid Analgesics (Opioids)IBA
10/2015 - 12/2000
3Pharmaceutical PreparationsIBA
12/2008 - 03/2001
3Formaldehyde (Formol)FDA Link
04/2003 - 06/2001
3Analgesics (Analgesic Drugs)IBA
07/2002 - 03/2001
2Levodopa (L Dopa)FDA LinkGeneric
01/2018 - 09/2015
2Haloperidol (Haldol)FDA LinkGeneric
09/2015 - 06/2000
2Dopamine (Intropin)FDA LinkGeneric
06/2015 - 12/2000
2Morphine (MS Contin)FDA LinkGeneric
12/2008 - 11/2002
2Guanosine 5'-O-(3-Thiotriphosphate)IBA
12/2001 - 07/2000
2Proteins (Proteins, Gene)FDA Link
12/2001 - 07/2000
28-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)IBA
06/2001 - 06/2000
2Serotonin (5 Hydroxytryptamine)IBA
06/2001 - 04/2000
1CorticosteroneIBA
01/2018
1Serotonin 5-HT1 Receptor AgonistsIBA
09/2015
1Serotonin 5-HT1 Receptor AntagonistsIBA
09/2015
1Peptide Hydrolases (Proteases)FDA Link
06/2015
1EnzymesIBA
06/2015
1Naltrexone (ReVia)FDA LinkGeneric
12/2008
1Gabapentin (Neurontin)FDA LinkGeneric
11/2002
1KetamineFDA LinkGeneric
11/2002
1Imipramine (Janimine)FDA LinkGeneric
11/2002
1Cholinergic Agents (Cholinergics)IBA
12/2001
1Scopolamine (Hyoscine)FDA Link
12/2001
1Fentanyl (Sublimaze)FDA LinkGeneric
03/2001
1Opiate AlkaloidsIBA
03/2001
1triphosphoric acid (triphosphate)IBA
07/2000
1GuanosineIBA
07/2000
1N- (2- (4- (2- methoxyphenyl)- 1- piperazinyl)ethyl)- N- (2- pyridinyl)cyclohexanecarboxamideIBA
04/2000
1nemonaprideIBA
04/2000
1Antipsychotic Agents (Antipsychotics)IBA
04/2000
1RacloprideIBA
04/2000

Therapy/Procedure

3Analgesia
04/2003 - 06/2001
1Injections
11/2002
1Self Administration (Administration, Self)
03/2001